"We're not saying that there's not a difference," says lead researcher Bruce G.Bender, Ph D, of National Jewish Medical and Research Center in Denver."And based on that study, I certainly wouldn't have wanted to face those Benadryl people on the road." In Bender's analysis, some studies involved self-reported levels of sedation, while others measured their ability to perform specific tasks."Obviously, in the old days when you only had sedating antihistamines, that's what you used, but you generally start out by having patients take them at bedtime.
"Today, most people would lead to nonsedating medications." And perhaps with good reason: Some 35 states in the U. have laws related to driving while impaired -- not only by alcohol, but also from antihistamines, says Cohen. "Zyrtec is a relatively non-sedating antihistamine, but it has a warning in the Physician's Desk Reference [which gives detailed information on prescribing drugs] about operating machinery when taking it," he tells Web MD.Examples include: receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of histamine.Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H Research into these drugs led to the discovery that they were H1 antagonists and also to the development of H2 antagonists, where H1 antihistamines affected the nose and the H2 antihistamines affected the stomach."The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.
The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD."They found the people taking Allegra or placebo drove well.